Indiana University Purdue University Indianapolis

Stephen L Boehm II Ph.D.

Director of Neuroscience Program, Associate Professor, Psychology

Education

2002-2005 Postdoctoral, Behavioral and Molecular Pharmacology, University of Texas at Austin.

1996-2002 Behavioral Neuroscience Ph.D., Oregon Health & Science University, Portland.

1990-1996 Psychology B. A., University of Northern Colorado, Greeley.

Current Research

Work in my lab seeks to understand how developmental and genetic factors influence loss of control over alcohol intake, or binge drinking. Alcohol-related behaviors thought to influence propensity to engage in binge-like alcohol drinking in mice are studied. We use mice of different developmental and genetic backgrounds to ask mechanistic questions about the complex relationships between brain and behavior. For example, we compare different genetic mouse models to assess age-specific sensitivity to alcohol's behavioral actions and determine how alcohol exposure during prenatal and early postnatal development influences that of adulthood. Moreover, we employ state-of-the-art techniques to study the relationships between brain and behavioral sensitivity to alcohol in mice, including site-specific microinjection into discrete brain regions and real-time PCR analysis of relative mRNA expression across brain structures to determine which neurotransmitter systems and brain structures are important modulators of alcohol-related behavior. Our hope is that such work will help elucidate the behavioral/brain mechanisms associated with alcohol behavioral sensitivity in humans and provide further insight into how those mechanisms influence (and are influenced by) binge alcohol drinking across development. Our work is supported by grants from the National Institute on Alcohol Abuse and Alcoholism and the Integrative Neuroscience Initiative on Alcoholism - West.

Select Publications

  • Moore EM, Serio KM, Goldfarb KJ, Stepanovska S, Linsenbardt DN, Boehm II SL (2007) GABAergic modulation of binge-like ethanol intake in C57BL/6J mice. Pharmacology, Biochemistry and Behavior, 88:105-113. PMCID: PMC2394855
  • Boehm II SL, Goldfarb KJ, Serio KM, Moore, EM, Linsenbardt DN (2008) Does context influence the duration of locomotor sensitization to ethanol in female DBA/2J mice? Psychopharmacology, 197:191-201. PMCID: PMC2279101
  • Boehm II SL, Moore EM, Walsh CD, Gross C, Cavelli A, Gigante E, Linsenbardt DN (2008) Using Drinking in the Dark to  model prenatal binge-like exposure to ethanol in C57BL/6J mice. Developmental Psychobiology, 50:566-578. PMCID: PMC2574727
  • Linsenbardt DN, Moore EM Gross CD, Goldfarb KJ, Blackman LC, Boehm II SL (2009) Sensitivity and tolerance to the hypnotic and ataxic effects of ethanol in adolescent and adult C57BL/6J and DBA/2J mice. Alcoholism: Clinical and Experimental Research, 33:1-13. PMCID: PMC2736547
  • Moore EM, Boehm II SL (2009) Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces ethanol intake in male C57BL/6J mice. Behavioral Neuroscience, 123:555-563. PMCID: PMC2732108
  • Linsenbardt DN, Boehm II SL (2009) Agonism of the endocannabinoid system modulates binge-like alcohol intake in male C57BL/6J mice: Involvement of the posterior ventral tegmental area. Neuroscience, 164:424-434. PMCID: PMC2762022
  • Moore EM, Mariani J, Linsenbardt DN, Melón LC, Boehm II SL (2010) C57BL/6J (but not DBA/2J) C57BL/6J (but not DBA/2J) Mice consume greater amounts of limited-access ethanol compared to adults and display continued elevated ethanol intake into adulthood. Alcoholism: Clinical and Experimental Research, 34:1-9. PMCID: PMC20102570
  • Linsenbardt DN, Boehm II SL (2010) Ethanol-induced locomotor sensitization in DBA/2J mice is associated with alterations in GABAA subunit gene expression and behavioral sensitivity to GABAA acting drugs. Pharmacology, Biochemistry, and Behavior, 95:359-366. PMCID: PMC20219525
  • Moore EM, Linsenbardt DN, Melón LC, Boehm II SL (2010) Ontogenetic differences in adolescent and adult C57BL/6J and DBA/2J mice: Anxiety-like, locomotor, and consummatory behaviors. Developmental Psychobiology, 53:141-56. PMCID: PMC20886536
  • Melón LC, Boehm II SL (2011) GABAA receptors in the posterior, but not anterior, ventral tegmental area mediate Ro15-4513 attenuation of binge-like ethanol consumption in C57BL/6J female mice. Behavioural Brain Research, 220:230-237. PMCID: PMC21320533
  • Linsenbardt DN, Moore EM, Griffin KD, Gigante E, Boehm II SL (2011) Tolerance to ethanol’s ataxic and locomotor effects following repeated binge-like ethanol intake using the DID model. Alcoholism: Clinical and Experimental Research, 35:1246-55. PMCID: PMC21410484
  • Melón LC, Boehm II SL (2011) Development of locomotor sensitization to ethanol in adult and adolescent mice: Comparison of the DBA/2J and C57BL/6J inbred mouse strains. Alcoholism: Clinical and Experimental Research, 35:1351-60. PMCID: PMC21410489
  • Linsenbardt DN, Boehm II SL (2012) Role of novelty and ethanol history in locomotor stimulation induced by binge-like ethanol intake. Alcoholism: Clinical and Experimental Research, 36:887-94. PMCID: PMC 22150802
  • Kruse LC, Linsenbardt DN, Boehm II SL (2012) Positive allosteric modulation of the GABAB receptor attenuates the locomtor stimulant actions of ethanol and alters the induction of locomotor sensitization. Alcohol, 46:455-462. PMCID: PMC 22560291